Tetracycline pleurodesis during active pulmonary-pleural air leak for prevention of recurrent pneumothorax.

摘要: Pleurodesis with a sclerosing agent was attempted in an animal model which pneumothorax active air leak created. Adult rabbits had small left thoracotomy and then 1-cm controlled cut the lung surface. Animals served as control, or tetracycline administered. The chest tube removed after stopped. were sacrificed 20 days. Group A control (6); group B powdered placed at thoracotomy; C, solution, 2 ml/kg, 25 mg/ml (4); D, 1 50 (10). Control showed few adhesions, pleura appeared to be normal by histologic examination. There spectrum of results tetracycline, but concentrated solution (group D) examination uniform pleurodesis thickening pleura. In D it took no longer for pulmonary seal than (control) rabbits. We conclude that is effective causing even when present. lung, however, must kept expanded so symphysis can occur between visceral parietal