Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T2 suppression
作者： Luning Wang , Wei Tang , Zipeng Zhen , Hongming Chen , Jin Xie
DOI: 10.1016/J.MRI.2014.02.016
关键词: Nuclear magnetic resonance 、 In vivo 、 Ex vivo 、 Chemistry 、 Iron oxide nanoparticles
摘要: Abstract In order to improve the detection specificity of iron oxide nanoparticles (IONPs) delivered tumors, we embedded saturation pulses into sweep imaging using Fourier transformation (SWIFT) sequence suppress long T 2 tissues and fat. Simulation Bloch equation was first conducted study behavior various lengths under different off-resonance conditions. MR experiments were then in vivo mouse xenografts a phantom consisting IONPs, vegetable oil, explanted tumor specimen, without with suppression 7 T magnetic field. For study, arginine-glycine-aspartate (RGD) coated 10 nm IONPs (RGD-IONPs) tumors implanted nude mice through both intra-tumor intravenous injections. Histological studies confirmed that RGD-IONPs efficiently homed RGD-integrin interaction. Compared conventional SWIFT, proposed method resulted sufficient on species but less influence short species. ex studies, significantly improved contrast-to-noise ratio (CNR) achieved between
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