Changes in the expression of lectins in human T lymphocyte membrane upon mitogenic stimulation

摘要: Surface lectins, specific for given sugar structures, are expressed on human T cells, as shown by flow cytofluorometry using F-neoglycoproteins bearing either beta- and alpha-D-galactosyl, beta-D-galactosyl 6-phosphate, or alpha-L-rhamnosyl groups, but not other groups (such alpha-D-mannosyl groups). After stimulation with Phaseolus vulgaris mitogen, the number of cells that bind 6-phosphate (6-P-beta-D-Galp lec+ cells) increased fourfold during first five days; these helper (CD4+) cells. Conversely, alpha-L-Rha belong to suppressor (CD8+) family their moderately increased. Upon concanavalin A, expressing lectin recognizing two days then decreased within next days. These results discussed regard implication lymphocyte membrane lectins in mechanism homing process.