Serum levels of ochratoxin A in dogs with chronic kidney disease (CKD): a retrospective study
作者： Valentina MEUCCI , Giacomo LUCI , Michele VANNI , Grazia GUIDI , Francesca PERONDI
DOI: 10.1292/JVMS.16-0226
关键词: Nephrotoxicity 、 Kidney disease 、 Medicine 、 Toxin 、 Physiology 、 Mycotoxin 、 Incidence (epidemiology) 、 Ochratoxin A 、 Creatinine 、 Animal feed
摘要: Ochratoxin A (OTA) is a mycotoxin produced by secondary metabolism of several fungi belonging to the genera Aspergillus and Penicillium. OTA potentially nephrotoxic, neurotoxic, immunotoxic carcinogenic in animal species humans. This toxin has been detected human food feed. The aim this study was determine blood samples healthy affected chronic kidney disease (CKD) dogs. CKD group showed higher incidence OTA-positivity than dogs (96 vs. 56%) significantly median value plasma concentration (0.008 0.144 ng/ml). No significant correlation observed between levels creatinine values first regarding detection dogs; presence nephropatic patients but not yet clear, if it correlated with progression disease.
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sci-hub.se 参考文章(26)
G. M. Szczech, W. W. Carlton, E. J. Hinsman, Ochratoxicosis in Beagle Dogs III. Terminal Renal Ultrastructural Alterations Veterinary Pathology. ,vol. 11, pp. 385- 406 ,(1974) , 10.1177/030098587401100501
Angela Mally, Herbert Zepnik, Paul Wanek, Erwin Eder, Karen Dingley, Heiko Ihmels, Wolfgang Völkel, Wolfgang Dekant, Ochratoxin A: lack of formation of covalent DNA adducts. Chemical Research in Toxicology. ,vol. 17, pp. 234- 242 ,(2004) , 10.1021/TX034188M
Won-Il Jeong, Sun Hee Do, Da-Hee Jeong, Jae-Yong Chung, Hai-Jie Yang, Dong-Wei Yuan, Il-Hwa Hong, Jin-Kyu Park, Moon-Jung Goo, Kyu-Shik Jeong, Canine renal failure syndrome in three dogs. Journal of Veterinary Science. ,vol. 7, pp. 299- 301 ,(2006) , 10.4142/JVS.2006.7.3.299
Annie Pfohl-Leszkowicz, Mariana Tozlovanu, Richard Manderville, Maja Peraica, Marcel Castegnaro, Vladislav Stefanovic, New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor. Molecular Nutrition & Food Research. ,vol. 51, pp. 1131- 1146 ,(2007) , 10.1002/MNFR.200700045
A. Mally, G.C. Hard, W. Dekant, Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats. Food and Chemical Toxicology. ,vol. 45, pp. 2254- 2260 ,(2007) , 10.1016/J.FCT.2007.05.021
John L. Richard, Some major mycotoxins and their mycotoxicoses--an overview. International Journal of Food Microbiology. ,vol. 119, pp. 3- 10 ,(2007) , 10.1016/J.IJFOODMICRO.2007.07.019
P. Songsermsakul, E. Razzazi-Fazeli, J. Böhm, J. Zentek, Occurrence of deoxynivalenol (DON) and ochratoxin A (OTA) in dog foods. Mycotoxin Research. ,vol. 23, pp. 65- 67 ,(2007) , 10.1007/BF02946027
S.C. Duarte, C.M. Lino, A. Pena, Mycotoxin food and feed regulation and the specific case of ochratoxin A: a review of the worldwide status Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment. ,vol. 27, pp. 1440- 1450 ,(2010) , 10.1080/19440049.2010.497166
K. Maaroufi, A. Achour, A. M. Betbeder, M. Hammami, F. Ellouz, E. E. Creppy, H. Bacha, Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in Tunisia Archives of Toxicology. ,vol. 69, pp. 552- 558 ,(1995) , 10.1007/S002040050211
E. Razzazi, J. Bohm, J. Grajewski, K. Szczepaniak, A. J. Kubber-Heiss, C. H. Iben, Residues of ochratoxin A in pet foods, canine and feline kidneys. Journal of Animal Physiology and Animal Nutrition. ,vol. 85, pp. 212- 216 ,(2001) , 10.1046/J.1439-0396.2001.00331.X