Current challenges in the treatment of epilepsy.

摘要: Significant progress in the classification, diagnosis, and pharmacologic management of epileptic seizures has occurred over past two decades, but epilepsy remains a therapeutic challenge. Clinical studies show that most patients with can have complete or almost seizure control optimally managed monotherapy employs traditional antiepileptic drug (AED). About half remaining obtain improved combination therapy, usually more adverse effects. In other half, remain refractory to treatment available drugs, problematic because intolerance. Advances understanding pathogenesis mechanisms action drugs provided basis for development new AEDs hold promise difficult-to-treat patients. this decade, number may overcome some disadvantages offer clinicians added options will become clinically available. These be fully evaluated their clinical potential meet existing challenges treatment.