Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model

摘要: The exact relationship between osteoporosis and osteoarthritis is still a matter for debate many. ovariectomised ewe frequently used as model osteoporosis, resulting in significant alterations bone morphometry turnover both trabecular subchondral after 1 year. This study examines whether ovariectomy has any impact on development of within the ovine stifle joint at same time point. In addition, we investigate there are correlations present articular cartilage degeneration microstructural parameters or rates underlying bone. Twenty-two sheep were examined this study; 10 underwent 12 kept controls. Five distinctive fluorochrome dyes administered intravenously 12-week intervals to groups, label sites turnover. All animals then sacrificed 12 months postoperatively. Although most specimens showed some evidence osteoarthritis, no measurable difference two groups was detected. Osteoarthritis associated with thinning plate, specifically cortical bone; however, whereas previous studies have suggested link not confirmed. No correlation found either plate. conclusion, despite fact that results marked morphological structural changes 1-year postoperatively, suggest it plays direct role aetiology osteoarthritis.