Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites.

摘要: Background Hypertension and its cardiovascular complications affect African Americans more severely than whites, a disparity variously ascribed to low birth weight, glomerular number, an exaggerated arteriolonephrosclerotic blood pressure response, inflammation-induced oxidative stress. Study Design Case series. Setting Participants Autopsy kidneys of 107 87 whites aged 18 65 years at single medical center between 1998 2005. Excluded were persons with known premorbid kidney disease; pathological findings severe arterioarteriolonephrosclerosis, nodular diffuse diabetic glomerulosclerosis, or nonischemic cardiomyopathy. Predictors & Outcomes Associations of: (1) race, age, sex, obesity, number (predictors) hypertension death from coronary artery (CAD) cerebrovascular disease (CVD; outcomes); (2) pressure, race changes, including chronic tubulointerstitial inflammation (outcomes). Measurements ascertained chart review heart weight. Cause determined autopsy findings. Birth weight obtained records (115 persons). Total (N glom ) estimated by using the dissector/fractionator technique. Arteriolosclerosis, cortical fibrosis, CD68 density measured morphometrically. Results 59 (55%) 32 (37%) classified as hypertensive. CAD CVD cause in 64 (33%) (9%), respectively. By multiple linear regression, ( P = 0.3) age 0.2), predicted N r 2 0.176). was associated American 0.04), older 0.01), but not 0.9), body mass index 0.4). only significant factor 0.01) younger there no racial differences degrees arteriolosclerosis, for any level increased pressure. Limitations The study is observational descriptive. Conclusions found could be attributed arteriolonephrosclerosis, density, without interacting contribution race.