Low glucose promotes CD133mAb-elicited cell death via inhibition of autophagy in hepatocarcinoma cells
作者： Haiyang Chen , Zaili Luo , Wen Sun , Cunzhen Zhang , Huanlin Sun
DOI: 10.1016/J.CANLET.2013.04.031
关键词: Programmed cell death 、 Antibody 、 Cancer research 、 Cell biology 、 Hepatocyte 、 Autophagy 、 Cancer stem cell 、 Doxorubicin 、 Cisplatin 、 Spheroid 、 Biology 、 Oncology
摘要: CD133 on cancer stem cells is a potential therapeutic target. In this study, antibody (CD133mAb) treatment resulted in cell death hepatoma LM3, HepG2, Hep3B and Huh-7 cells, especially under low glucose condition. The also inhibited formation of spheroids, colonies, xenograft tumors. Ectopic enabled hepatocyte L02 to be suppressed by CD133mAb increased spheroid formation. caused primary HCC sensitized them Doxorubicin Cisplatin. effect was attributed suppressing autophagy promoting necrotic death. Therefore, targeting condition approach for hepatocarcinomas.
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