Lymphocyte Death, p53, and the Problem of the “Undead” Cell

作者: D. J. Harrison , S. E. M. Howie , A. H. Wyllie

DOI: 10.1007/978-3-642-79437-7_9

关键词: LymphocyteT lymphocyteImmunologyGerminal centerBiologyCytotoxic T cellImmune systemCancer researchTumor suppressor geneApoptosisProgrammed cell death

摘要: Apoptosis is involved in many facets of the development and homeostatic regulation immune system (Cohen 1993), including elimination self-reactive thymocytes, selection B lymphocytes within germinal centres, memory T cells killing target by activated cytotoxic (Jenkinson et al. 1989; Finkel 1991; Berke Liu Akbar 1993).

参考文章(90)
Tomooka Y, Yagi T, Tsukada T, Takeda N, Nishikawa S, Ueda Y, Abe S, Tokunaga T, Suda Y, Takai S, Enhanced proliferative potential in culture of cells from p53-deficient mice Oncogene. ,vol. 8, pp. 3313- 3322 ,(1993)
B. C. Giovanella, M. A. Tainsky, M. Harvey, R. S. Weiss, A. T. Sands, A. Bradley, R. W. Wiseman, M. E. Hegi, L. A. Donehower, P. Pantazis, In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene. ,vol. 8, pp. 2457- 2467 ,(1993)
N. Goldfinger, V. Rotter, R. Aloni-Grinstein, I. Alboum, I. Zan-Bar, Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage Oncogene. ,vol. 8, pp. 3297- 3305 ,(1993)
R. Barrera, J. W. Said, H. P. Koeffler, I. P. Shintaku, H. Nakamura, Immunohistochemical analysis of p53 expression in malignant lymphomas. American Journal of Pathology. ,vol. 141, pp. 1343- 1348 ,(1992)
K S Sellins, J J Cohen, Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. Journal of Immunology. ,vol. 139, pp. 3199- 3206 ,(1987)
G Brandner, M Fritsche, C Haessler, Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene. ,vol. 8, pp. 307- 318 ,(1993)
Yoshihide Tsujimoto, Naoto Itoh, Shigekazu Nagata, Effect of bcl-2 on fas antigen-mediated cell death Journal of Immunology. ,vol. 151, pp. 621- 627 ,(1993)
H. Bluethmann, K. Berry, Tong Zhou, J. D. Mountz, J. Eldridge, Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse. Journal of Immunology. ,vol. 150, pp. 3651- 3667 ,(1993)
J J Ryan, R Danish, C A Gottlieb, M F Clarke, Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells. Molecular and Cellular Biology. ,vol. 13, pp. 711- 719 ,(1993) , 10.1128/MCB.13.1.711
CA Purdie, DJ Harrison, A Peter, L Dobbie, S White, SE Howie, DM Salter, CC Bird, AH Wyllie, ML Hooper, None, Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene Oncogene. ,vol. 9, pp. 603- 609 ,(1994)