Interventions for nausea and vomiting in early pregnancy.

摘要: Background Nausea, retching and vomiting are very commonly experienced by women in early pregnancy. There considerable physical, social psychological effects on who experience these symptoms. This is an update of a review interventions for nausea pregnancy last published 2014. Objectives To assess the effectiveness safety all nausea, pregnancy, up to 20 weeks’ gestation. Search methods We searched Cochrane Pregnancy Childbirth Group’s Trials Register, Complementary Medicine Field's Register (19 January 2015) reference lists retrieved studies. Selection criteria All randomised controlled trials any intervention We excluded hyperemesis gravidarum, which covered another review. also quasi-randomised using cross-over design. Data collection analysis Four authors, pairs, reviewed eligibility independently evaluated risk bias extracted data included trials. Main results Forty-one involving 5449 women, met inclusion criteria. These many interventions, including acupressure, acustimulation, acupuncture, ginger, chamomile, lemon oil, mint vitamin B6 several antiemetic drugs. were no studies dietary other lifestyle interventions. Evidence regarding P6 auricular (ear) acupressure acustimulation point was limited. Acupuncture (P6 or traditional) showed significant benefit The use ginger products may be helpful but evidence limited not consistent, though three recent support over placebo. only from pharmacological agents B6, Doxylamine-pyridoxoine anti-emetic drugs relieve mild moderate vomiting. little information maternal fetal adverse outcomes psychological, economic outcomes. We unable pool findings most due heterogeneity study participants, comparison groups, measured reported. methodological quality mixed. Risk low related performance bias, detection attrition studies. Selection unclear almost half did fully clearly report pre-specified outcomes. Authors' conclusions Given high prevalence health professionals need clear guidance about effective safe based systematically evidence. lack high-quality particular intervention. same as saying that studied ineffective, there insufficient strong one difficulties interpreting pooling results this highlight specific, consistent justified approaches measurement research