Limonin attenuates the stemness of breast cancer cells via suppressing MIR216A methylation.
作者： Zhou Su , Caihong Wang , Deyu Chang , Xiuna Zhu , Chunmei Sai
DOI: 10.1016/J.BIOPHA.2019.108699
关键词: Chemistry 、 Toxicity 、 Tumor progression 、 WNT3A 、 Breast cancer 、 Cell 、 Limonin 、 Cancer research 、 Methylation 、 Wnt signaling pathway
摘要: Limonin has been shown to exert anti-inflammatory effects, however, its roles in tumor progression remain unclear. This work aims investigate the and related mechanism of limonin stemness breast cancer cells. Here, we found that attenuated cells a concentration-dependent manner, evident by decreasing capacity cell spheroid formation, expression markers ALDH1 activity, whereas had no toxicity on non-tumorigenic Additionally, enhanced adriamycin sensitivity resistance adriamycin-resistant Mechanistically, decreased MIR216A methylation level thus increased miR-216a-3p expression. Furthermore, could directly bind WNT3A inactivated Wnt/β-catenin pathway. Therefore, our results indicate attenuate chemoresistance via inhibiting subsequently suppressing
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