Brain functional correlates of working memory: reduced load-modulated activation and deactivation in aging without hyperactivation or functional reorganization

摘要: We aimed to identify brain functional correlates of working memory performance in aging, hopes facilitating understanding mechanisms that promote better versus worse late-life. Among 64 healthy adults, aged 23 78, we examined the relationship between age, performance, and response during task performance. focused on association load-modulated individual differences whether these function-performance relationships differed with age. As expected, older age was associated poorer Older also reduced activation including bilateral prefrontal parietal regions left caudate as well deactivation medial cortex. Contrary findings hyperactivation found no evidence increased Positive associations identified did not differ Our suggest neural underlying are age-invariant across adulthood, argue against a pattern reorganization aging. Results discussed within broader literature, which significant heterogeneity studies has been common.