Assessing the Effectiveness and Public Health Impact of Rotavirus Vaccines after Introduction in Immunization Programs

摘要: Two new vaccines against severe rotavirus gastroenteritis that have high efficacy in middle- and high-income countries recently been licensed many worldwide. Clinical trials low-income Africa Asia are ongoing. Experience gained through studies of natural infection the clinical for current previous indicate that, as begin to introduce these newly approved into routine childhood immunization programs, monitoring their performance real world settings should be a priority. Key epidemiological considerations postlicensure period include (1) how vaccine will perform disease under public health use; (2) vaccination impact epidemiology with regard burden death, age distribution cases, seasonality, serotype distribution; (3) whether sufficient on transmission reduce unvaccinated groups; (4) confer protection first 3 years life, when most mortality associated occur. Monitoring focus allow parents, care providers, decision makers appreciate benefits reducing disease. It also assessment effectiveness programmatic use need modifying schedules or formulations enhance immunization. In this article, we review data protective 2 vaccines, emphasis issues particularly important consideration introduced infant programs.