Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis.
作者： Herbert B Newton
关键词: Tumor suppressor gene 、 Protein kinase B 、 RPTOR 、 Cancer research 、 PTEN 、 Glioma 、 Wortmannin 、 Targeted therapy 、 PI3K/AKT/mTOR pathway 、 Medicine
摘要: Brain tumors are a diverse group of malignancies that remain refractory to conventional treatment approaches. Molecular neuro-oncology has now begun clarify the transformed phenotype brain and identify oncogenic pathways might be amenable targeted therapy. Activity phosphoinositide 3´ kinase (PI3K)/Akt pathway is often upregulated in due excessive stimulation by growth factor receptors Ras. Loss function tumor suppressor gene PTEN also frequently contributes upregulation PI3K/Akt. Several compounds, such as wortmannin LY-294002, can target PI3K inhibit activity this pathway. The mammalian rapamycin (mTOR) an important regulator cell metabolism Akt. Clinical trials CCI-779, inhibitor mTOR, ongoing recurrent malignant glioma patients. sonic hedgehog/PTCH involved tumorigenesis some familial sporadic medulloblastomas. This b...
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