Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograft.

摘要: Monoclonal antibodies raised to peptide sequences of vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibited C6 tumors growing subcutaneously in nude mice. Immunohistochemical analysis demonstrated antibody targeting blood vessels, tumor cells, macrophages. A control no inhibition or uptake. An FLT-1 impaired microvascular maturation diminished accumulation infiltrating The affinity for microvasculature cells immunohistochemistry human glioblastoma multiforme. Targeting its receptors has potential treatment central nervous system. presents an attractive target due presence on multiple cell types.