VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
作者： Myriam Grunewald , Inbal Avraham , Yuval Dor , Esther Bachar-Lustig , Ahuva Itin
DOI: 10.1016/J.CELL.2005.10.036
关键词: Paracrine signalling 、 Immunology 、 Chemokine 、 Homing (hematopoietic) 、 Progenitor cell 、 Angiogenesis 、 Cancer research 、 Growth factor 、 Biology 、 Myofibroblast 、 Neovascularization
摘要: Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and mechanisms are unclear. We show that endothelial growth factor VEGF is sufficient for organ homing mononuclear myeloid cells required perivascular positioning retention. Recruited bone marrow-derived (RBCCs) summoned by serve a function distinct from progenitor cells. Retention RBCCs in close proximity to vessels mediated SDF1, chemokine induced activated myofibroblasts. enhance situ proliferation via secreting proangiogenic activities locally activities. Precluding strongly attenuated response addition purified enhanced angiogenesis excision wounds. Together, data suggest model VEGF-programmed adult highlighting essential paracrine role recruited SDF1
core.ac.uk
unirioja.es
elsevier.com
sci-hub.se 参考文章(42)
J Nissanov, L M Gruver, R W Tuman, J M Fortunato, Automatic vessel segmentation and quantification of the rat aortic ring assay of angiogenesis Laboratory Investigation. ,vol. 73, pp. 734- 739 ,(1995)
Stefano Chimenti, Eleonora Carlo, Serge Masson, Antonio Bai, Roberto Latini, Myocardial infarction: animal models. Methods in molecular medicine. ,vol. 98, pp. 217- 226 ,(2004) , 10.1385/1-59259-771-8:217
David Lyden, Koichi Hattori, Sergio Dias, Carla Costa, Pamela Blaikie, Linda Butros, Amy Chadburn, Beate Heissig, Willy Marks, Larry Witte, Yan Wu, Daniel Hicklin, Zhenping Zhu, Neil R. Hackett, Ronald G. Crystal, Malcolm A.S. Moore, Katherine A. Hajjar, Katia Manova, Robert Benezra, Shahin Rafii, Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth Nature Medicine. ,vol. 7, pp. 1194- 1201 ,(2001) , 10.1038/NM1101-1194
Erik De Clercq, The bicyclam AMD3100 story Nature Reviews Drug Discovery. ,vol. 2, pp. 581- 587 ,(2003) , 10.1038/NRD1134
A.A. Kocher, M.D. Schuster, M.J. Szabolcs, S. Takuma, D. Burkhoff, J. Wang, S. Homma, N.M. Edwards, S. Itescu, Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function Nature Medicine. ,vol. 7, pp. 430- 436 ,(2001) , 10.1038/86498
Gabriele Bergers, Rolf Brekken, Gerald McMahon, Thiennu H. Vu, Takeshi Itoh, Kazuhiko Tamaki, Kazuhiko Tanzawa, Philip Thorpe, Shigeyoshi Itohara, Zena Werb, Douglas Hanahan, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Nature Cell Biology. ,vol. 2, pp. 737- 744 ,(2000) , 10.1038/35036374
B Barleon, S Sozzani, D Zhou, HA Weich, A Mantovani, D Marme, Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 Blood. ,vol. 87, pp. 3336- 3343 ,(1996) , 10.1182/BLOOD.V87.8.3336.BLOODJOURNAL8783336
A Orpana, H Mänpää, K Alitalo, P Salven, H Joensuu, Serum vascular endothelial growth factor is often elevated in disseminated cancer. Clinical Cancer Research. ,vol. 3, pp. 647- 651 ,(1997)
Tamar Licht, Lilia Tsirulnikov, Hadas Reuveni, Talia Yarnitzky, Shmuel A. Ben-Sasson, Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood. ,vol. 102, pp. 2099- 2107 ,(2003) , 10.1182/BLOOD-2002-12-3634
Jalees Rehman, Jingling Li, Christie M. Orschell, Keith L. March, Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors Circulation. ,vol. 107, pp. 1164- 1169 ,(2003) , 10.1161/01.CIR.0000058702.69484.A0