PTEN Decreases in Vivo Vascularization of Experimental Gliomas in Spite of Proangiogenic Stimuli
作者： E. Antonio Chiocca , Edyta Tyminski , Hiroaki Wakimoto , James P. Basilion , Kinya Terada
DOI:
关键词: Neovascularization 、 Glioma 、 PTEN 、 Tumor suppressor gene 、 Epidermal growth factor receptor 、 Mutation 、 Angiogenesis 、 Biology 、 Cancer research 、 Gene expression
摘要: Approximately 30-40% of malignant glial tumors exhibit mutations in the tumor suppressor gene, PTEN/MMAC. Additionally, these are associated with (a) epidermal growth factor receptor (EGFR), leading to a pro-oncogenic constitutive activation, as well amplification its and/or (b) p53, disrupting normal cellular homeostatic processes. Whereas PTEN/MMAC has been shown possess antiangiogenic action, constitutively active EGFR or p53 gene defects have proangiogenic action. In this article, we asked if transfer into human glioma cells that inactivating but also express either (U87DeltaEGFR cells) an mutation (U251 still display inhibited angiogenesis orthotopic and ectopic models gliomas. Human xenografts treated exhibited significantly decreased vascularity both model. Taken combination, results provide strong evidence PTEN/MMAC's role regulating even presence signals provided by activation inactivation.
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