Tumor hypoxia, reoxygenation and oxygenation strategies: possible role in photodynamic therapy.
作者： Isabel Freitas , Gian Franco Baronzio
DOI: 10.1016/1011-1344(91)80264-I
关键词: Oxygenation 、 Hypoxia (medical) 、 Photodynamic therapy 、 Cancer research 、 Necrosis 、 Tumor hypoxia 、 Interstitial fluid 、 Immunology 、 Clonogenic assay 、 Biology 、 Tumor Oxygenation
摘要: The concept of hypoxia and its role in tumor therapy are currently under re-evaluation. Poor oxygenation is no longer visualized as an independent feature promoting necrosis resistance to treatments, but rather one the several interdependent microenvironmental parameters associated with impaired blood perfusion. Tumor cells display survival strategies remain clonogenic for long periods nutrient-deprived situations. Reoxygenation may cause lethal damage, improve response therapy, or else allow cell variants adapted resume proliferation enhanced aggressiveness treatment. supply parameters, status metabolism malignant discussed here from standpoint photodynamic therapy. interstitial fluid oxygen- sensitizer-carrier discussed. Techniques assessing mapping hypoxic territories described. Strategies locally improving levels selectively destroying populations outlined.
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