Factors influencing activities of biotransformation enzymes, concentrations and compositional patterns of organochlorine contaminants in members of a marine food web.

摘要: Abstract The accumulation of polychlorinated biphenyls (PCBs; 34 congeners), ∑DDT ( p , ′-DDT, o ′-DDD, ′-DDD and ′-DDE), chlordanes (∑CHL; trans -chlordane, cis -nonachlor, -nonachlor oxychlordane), hexachlorocyclohexanes (∑HCH; α-, β- γ-isomers), hexachlorobenzene (HCB) mirex was investigated in members a marine food web from the Hvaler Torbjornskjaer archipelago, south–eastern Norway. species studied were bullrout Myoxocephalus scorpius ), cod Gadus morhua herring gull Larus argentatus ) harbour seal Phoca vitulina ). Furthermore, hepatic biotransformation enzyme activities (ethoxyresorufin- O -deethylase (EROD), pentoxyresorufin- -depentylase (PROD) glutathione S -transferase (GST)) measured all species. objectives study to investigate factors causing intraspecies variation enzymes, as well concentrations compositional patterns organochlorines (OCs). High correlations between EROD PROD found species, suggesting single, common catalyst, CYP1A, render assay questionable biomarker for CYP2B inducers wildlife. GST are shown be dependent on biological factors, such age (in seal) sex bullrout). In fish, OC vary sexes, likely due differences fat deposition strategies possibly dimorphism. seals, OCs with age, owing selective transfer mother pup utero mainly through lactation, but also specific xenobiotic metabolising capacity.