Adverse effects of perioperative transfusion on patients with stage III and IV gastric cancer

摘要: Background: The degree of immunomodulation by perioperative blood transfusion and its resultant effects on cancer surgery are a subject controversy. We evaluated the prognostic gastric surgery. Methods: A total 1710 patients who underwent curative gastrectomy for from 1991 to 1995 were retrospectively reviewed. Uni- multivariate analyses incidence, amount, timing transfusions comparison clinicopathological features performed. Results: higher incidence was associated with female sex, large tumors, upper-body location, Borrmann type III or IV lesions, longer operations, gastrectomies, splenectomies, D3 more extended lymphadenectomy. tumors in transfused group advanced depth invasion nodal classification. More frequent tumor recurrences found group. dose-response relationship between amount prognosis evident. Subgroup according stage showed significant differences stages nontransfused groups. On analysis, shown be an independent risk factor recurrence poor prognosis. Conclusions: These results suggest that is unfavorable factor. It thus better refrain unnecessary give least when inevitable, especially those cancers.