Parents with periodontitis impact the subgingival colonization of their offspring.

摘要: Early acquisition of a pathogenic microbiota and the presence dysbiosis in childhood is associated with susceptibility to familial aggregation periodontitis. This longitudinal interventional case-control study aimed evaluate impact parental periodontal disease on oral pathogens their offspring. Subgingival plaque clinical metrics were collected from 18 parents history generalized aggressive periodontitis children (6-12 years age), periodontally healthy at baseline following professional prophylaxis. 16S rRNA amplicon sequencing revealed that primary source child's microbiome, affecting microbial diversity. Children preferentially colonized by Filifactor alocis, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, Fusobacterium nucleatum several species belonging genus Selenomonas even absence periodontitis, these controlled inter-bacterial interactions. These also emerged as robust discriminators signatures Plaque control did not modulate this pattern, attesting microbiome's resistance change once it has been established. highlights critical role played colonization patterns offspring early periodontitis-related underscores need for greater surveillance preventive measures families patients.