A novel method for the analysis of the substitution pattern of O-methyl-α- and β-1,4-glucans by means of electrospray ionisation-mass spectrometry/collision induced dissociation
作者： Roland Adden , Petra Mischnick
DOI: 10.1016/J.IJMS.2004.11.016
关键词: Mass spectrum 、 Fragmentation (mass spectrometry) 、 Adduct 、 Medicinal chemistry 、 Mass spectrometry 、 Organic chemistry 、 Methyl cellulose 、 Methylation 、 Disaccharide 、 Collision-induced dissociation 、 Chemistry
摘要: Abstract The substitution pattern of O -methyl amylose and cellulose was analysed after per- -methylation (Me- d 3 ), partial hydrolysis by subsequent ESI-MS/CID the sodium (MS 2 ) lithium adducts ). Based on previous studies about influence regioselective fragmentation pathways malto- cello-oligosaccharides, we could calculate contribution a certain methyl to distinct signal in reproducible ESI-MS daughter spectrum. Signal intensities obtained from each -methyl- disaccharide were distributed corresponding patterns accumulated for all peaks mother mass Data not sufficient disaccharides bearing deuteromethyl groups combination 4, 3, or 4 2. Further independent information adducts. Monomer composition celluloses amyloses this novel approach very good agreement with reference data GLC partially methylated glucitol acetates complete hydrolysis, reduction acetylation.
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