PKG II Inhibits EGF/EGFR-Induced Migration of Gastric Cancer Cells
作者： Lu Jiang , Ting Lan , Yongchang Chen , Jianrong Sang , Yueying Li
DOI: 10.1371/JOURNAL.PONE.0061674
关键词: Signal transduction 、 Cancer cell 、 Phosphorylation 、 Biology 、 Epidermal growth factor 、 Cell culture 、 MAPK/ERK pathway 、 Cell biology 、 Cyclic GMP-Dependent Protein Kinase Type II 、 Epidermal growth factor receptor 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Our previous research results showed that Type II cGMP dependent protein kinase (PKG II) could block the activation of epidermal growth factor receptor (EGFR) and consequently inhibit proliferation related MAPK/ERK-mediated signal transduction gastric cancer cell line BGC-823, suggesting PKG might other EGFR-triggered pathways biological activities cells. This paper was designed to investigate potential inhibition on EGF/EGFR-induced migration activity pathways.
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