TGF-β inhibitors for the treatment of cancer
作者： Michael Lahn , Susanne Kloeker , Brandi S Berry
DOI: 10.1517/13543784.14.6.629
关键词: Small molecule 、 Cancer 、 Cancer treatment 、 Pharmacology 、 Antisense oligonucleotides 、 Carcinogenesis 、 Knockout mouse 、 Monoclonal antibody 、 Biology 、 Transforming growth factor
摘要: Advances in understanding the role of transforming growth factor (TGF)-β tumorigenesis have led to development TGF-β inhibitors for cancer treatment. Three platforms evolved: antisense oligonucleotides, monoclonal antibodies and small molecules. In this review, current stage each known inhibitor will be discussed. As part risk/benefit assessment inhibitors, effects deficiency mice, non-clinical toxicology studies with rats, clinical against summarised.
informapharmascience.com参考文章(115)
GREGORY P. BOIVIN, IIONA ORMSBY, JESSICA JONES-CARSON, BARBARA A. O'TOOLE, THOMAS DOETSCHMAN, Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions Transgenic Research. ,vol. 6, pp. 197- 202 ,(1997) , 10.1023/A:1018490007745
A. B. Kier, T. Doetschman, G. P. Boivin, I. E. Orsmby, R. J. Diebold, M. J. Eis, B. A. O'Toole, Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice. American Journal of Pathology. ,vol. 146, pp. 276- 288 ,(1995)
Scott I Abrams, Role of anti-CTLA-4 therapies in the treatment of cancer. Current Opinion in Molecular Therapeutics. ,vol. 6, pp. 71- ,(2004)
Cordeiro Mf, Technology evaluation: lerdelimumab, Cambridge Antibody Technology. Current Opinion in Molecular Therapeutics. ,vol. 5, pp. 199- 203 ,(2003)
S M Seyedin, A Y Thompson, H Bentz, D M Rosen, J M McPherson, A Conti, N R Siegel, G R Galluppi, K A Piez, Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 261, pp. 5693- 5695 ,(1986) , 10.1016/S0021-9258(17)38436-3
Gillian S. Ashcroft, Xiao Yang, Adam B. Glick, Michael Weinstein, John J. Letterio, Diane E. Mizel, Mario Anzano, Teresa Greenwell-Wild, Sharon M. Wahl, Chuxia Deng, Anita B. Roberts, Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nature Cell Biology. ,vol. 1, pp. 260- 266 ,(1999) , 10.1038/12971
Liisa Pertovaara, Arja Kaipainen, Tuija Mustonen, Arto Orpana, Napoleone Ferrara, Olli Saksela, Kari Alitalo, None, Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. Journal of Biological Chemistry. ,vol. 269, pp. 6271- 6274 ,(1994) , 10.1016/S0021-9258(17)37365-9
D Inenaga, L Ellingsworth, J R Dasch, W Waegell, D R Pace, Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. Journal of Immunology. ,vol. 142, pp. 1536- 1541 ,(1989)
Louise Showe, Kapaettu Satyamoorthy, Meenhard Herlyn, Richelle Takemoto, Paul Robbins, Helmut Schaider, Carola Berking, Transforming Growth Factor-β1 Increases Survival of Human Melanoma through Stroma Remodeling Cancer Research. ,vol. 61, pp. 8306- 8316 ,(2001)
Masatoshi Nomura, En Li, Smad2 role in mesoderm formation, left-right patterning and craniofacial development Nature. ,vol. 393, pp. 786- 790 ,(1998) , 10.1038/31693