Assay of Hyoscyamine, Atropine, Scopolamine, and Phenobarbital in Unit Doses of Tablets and Elixirs
作者： Rupert O. Zimmerer , Lee T. Grady
关键词: Atropine 、 Scopolamine 、 Chemistry 、 Dosage form 、 Pharmacology 、 Phenobarbital 、 Chromatography 、 Hyoscyamine 、 Homatropine 、 Pharmaceutical Science
摘要: A gas chromatographic assay for unit dose quantities of scopolamine and atropine-hyoscyamine was developed tablets elixirs containing phenobarbital. The method allows the complete forms. Standards assayed with precisions 4.8% scopolamine, 6 mcg./unit dose, 2.5% at 100 mcg./dose, 1.0% phenobarbital (spectro-photometric) 16 mg./dose. Homatropine served as extracted internal standard. Derivatives alkaloids were unnecessary using properly cured columns.
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