Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice.
作者： Kazuyuki Yamada , Etsuko Wada , Keiji Wada
DOI: 10.3109/07853890008998831
关键词: Neuromedin B receptor 、 Bombesin 、 Endocrinology 、 Gastrin-releasing peptide receptor 、 Bombesin-like peptides 、 Internal medicine 、 Neuromedin B 、 Bombesin receptor 、 Bombesin Receptor Subtype-3 、 Receptor 、 Biology
摘要: Bombesin (BN)-like peptides and receptors for these are widely distributed in mammalian peripheral tissues the central nervous system. The physiological behavioural functions of have been clarified by both vivo vitro studies. In spite intensive investigations, endogenous BN-like remain unclear. order to specify functions, our group another laboratory generated gene targeting mutant mice that lack one three peptide found mammals, ie neuromedin B receptor (NMB-R; BB1), gastrin-releasing (GRP-R; BB2), or bombesin subtype-3 (BRS-3; BB3). Using mouse, we unexpected phenotypes, such as hyperphagia obesity BRS-3-deficient abnormal social behaviour GRP-R-deficient mouse. present study, most recent findings addition previous studies discuss related feeding...
informahealthcare.com参考文章(99)
Carol L. McLaughlin, Role of peptides from gastrointestinal cells in food intake regulation. Journal of Animal Science. ,vol. 55, pp. 1515- 1527 ,(1982) , 10.2527/JAS1982.5561515X
A.-M. Lebacq-Verheyden, J. Trepel, E. A. Sausville, J. F. Battey, Bombesin and Gastrin-Releasing Peptide: Neuropeptides, Secretogogues, and Growth Factors Peptide Growth Factors and Their Receptors II. pp. 71- 124 ,(1990) , 10.1007/978-3-642-74781-6_3
Z. Fathi, M.H. Corjay, H. Shapira, E. Wada, R. Benya, R. Jensen, J. Viallet, E.A. Sausville, J.F. Battey, BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. Journal of Biological Chemistry. ,vol. 268, pp. 5979- 5984 ,(1993) , 10.1016/S0021-9258(18)53415-3
Hiroko Ohki-Hamazaki, Kei Watase, Kazutoshi Yamamoto, Hiroo Ogura, Mariko Yamano, Kazuyuki Yamada, Hiroshi Maeno, Junko Imaki, Sakae Kikuyama, Etsuko Wada, Keiji Wada, Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity Nature. ,vol. 390, pp. 165- 169 ,(1997) , 10.1038/36568
Hiroko Ohki-Hamazaki, Yasushi Sakai, Katsuo Kamata, Hiroo Ogura, Shigeru Okuyama, Kei Watase, Kazuyuki Yamada, Keiji Wada, Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor The Journal of Neuroscience. ,vol. 19, pp. 948- 954 ,(1999) , 10.1523/JNEUROSCI.19-03-00948.1999
Raphael Lamprecht, Shoshi Hazvi, Yadin Dudai, cAMP Response Element-Binding Protein in the Amygdala Is Required for Long- but not Short-Term Conditioned Taste Aversion Memory The Journal of Neuroscience. ,vol. 17, pp. 8443- 8450 ,(1997) , 10.1523/JNEUROSCI.17-21-08443.1997
Andrew J. Silver, James F. Flood, John E. Morley, Effect of gastrointestinal peptides on ingestion in old and young mice. Peptides. ,vol. 9, pp. 221- 225 ,(1988) , 10.1016/0196-9781(88)90254-9
Charles W. Malsbury, Mario O. Miceli, Effects of putative satiety peptides on feeding and drinking behavior in golden hamsters (Mesocricetus auratus). Behavioral Neuroscience. ,vol. 99, pp. 1192- 1207 ,(1985) , 10.1037//0735-7044.99.6.1192
Robin L. Bowers, Christopher D. Herzog, Bombesin effects on responding maintained by a fixed interval schedule of food reinforcement. Peptides. ,vol. 12, pp. 1435- 1436 ,(1991) , 10.1016/0196-9781(91)90229-I
William D. Hamrick, Donald A. Wilson, Regina M. Sullivan, Neural correlates of memory for odor detection conditioning in adult rats Neuroscience Letters. ,vol. 163, pp. 36- 40 ,(1993) , 10.1016/0304-3940(93)90223-8