Long-chain polyunsaturated fatty acids are consumed during allergic inflammation and affect T helper type 1 (Th1)- and Th2-mediated hypersensitivity differently.

摘要: P>Studies have shown that atopic individuals decreased serum levels of n-3 fatty acids. Indicating these compounds may a protective effect against allergic reaction and/or are consumed during inflammation. This study investigated whether fish (n-3) or sunflower (n-6) oil supplementation affected T helper type 1 (Th1)- and Th2-mediated hypersensitivity in the skin airways, respectively, acid profile changed inflammatory response. Mice were fed regular chow, chow + 10% oil. immunized with ovalbumin (OVA) resolved Th1 Th2 adjuvant. For hypersensitivity, mice challenged OVA footpad. Footpad swelling, OVA-induced lymphocyte proliferation cytokine production draining lymph node evaluated. In airway model (Th2), intranasally resulting immunoglobulin (Ig)E eosinophilic lung infiltration measured. model, OVA-specific cells proliferated less produced interferon (IFN)-gamma, tumour necrosis factor (TNF) interleukin (IL)-6 oil-fed versus controls. swelling was reduced marginally. contrast, more IgE had slightly higher proportions eosinophils infiltrate. A significant fall long-chain acids accompanied challenge inflammation model. Fish affects immune responses conversely; consumption occurs Th2-driven The latter observation explain association between low