Molecular interactions of cord factor with dipalmitoylphosphatidylcholine monolayers: implications for lung surfactant dysfunction in pulmonary tuberculosis.
作者： G. Chimote , R. Banerjee
DOI: 10.1016/J.COLSURFB.2008.03.004
关键词: Biophysics 、 Pulmonary surfactant 、 Dipalmitoylphosphatidylcholine 、 Monolayer 、 Surface roughness 、 Entropy of mixing 、 Cord factor 、 Pulmonary tuberculosis 、 Chromatography 、 Chemistry 、 Langmuir
摘要: Abstract Molecular interactions between mycobacterial cell wall lipid, cord factor (CF) and the abundant surfactant dipalmitoylphosphatidylcholine (DPPC) were investigated using Langmuir monolayers at physiological temperatures (37 °C). Surface topography of films was visualized by atomic force microscopy (AFM). Thermodynamic behavior mixed evaluated investigating molecular area excess, excess Gibbs free energy mixing maximum compressibility modulus (SCM max ). Cord formed immiscible thermodynamically unstable with DPPC. Monolayer presence altered physical state DPPC from liquid condensed to expanded lowering SCM 160 40 mN/m, respectively. AFM imaging exhibited smooth homogenous surface which in markedly appearance aggregates increased roughness. The results highlight capacity disturb monolayer organization structure. Interfacial fluidization. Lung function is attributed its ability form well packed low films. Such suggest a dysfunction lung pulmonary tuberculosis due
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