Orthogonal array design for optimization of hollow-fiber-based liquid-phase microextraction combined with high-performance liquid chromatography for study of the pharmacokinetics of magnoflorine in rat plasma.
作者： Jun Zhou , Jiang Bing Sun , Ping Zheng , Jing Liu , Zhao Hui Cheng
DOI: 10.1007/S00216-012-6013-8
关键词: Detection limit 、 Chromatography 、 Calibration curve 、 High-performance liquid chromatography 、 Orthogonal array 、 Analyte 、 Magnoflorine 、 Analytical chemistry 、 Fiber 、 Chemistry 、 Extraction (chemistry)
摘要: In this work, a new sample-preparation method based on hollow-fiber liquid-phase microextraction (HF-LPME) was developed for analysis of magnoflorine in rat plasma. Analysis accomplished by reversed-phase high-performance liquid chromatography (HPLC), with ultraviolet detection use photodiode-array detector. An orthogonal array design (OAD) found to be effective optimization major conditions which may affect the efficiency HF-LPME. Under optimized (pH donor and acceptor phases 12 2.0, respectively; extraction time 20 min; stirring speed 800 rpm; addition 10 % (w/v) salt), preconcentration factor 355. Calibration curves reasonable linearity (r2 ≥ 0.9994) were obtained range 10–1000 ng mL−1. Intra-day inter-day precision (RSD) <5.5 limit (LOD) analyte 3.0 mL−1 (S/N = 3). The validated successfully used pharmacokinetic studies plasma after intravenous administration.
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