The relationship between real world ambulatory activity and falls in incident Parkinson's disease: Influence of classification scheme

摘要: INTRODUCTION: Few studies have categorized falls in early Parkinson's disease (PD) and little is known about incidence evolution. Fall frequency are reported to be 'U' shaped with respect severity may influenced by time spent engaged ambulatory activity. METHODS: Twelve months prospective an incident PD cohort (n = 111) were the relationship between activity was examined a subgroup 83). events collected using standardised protocols fall (non-faller, single fall, recurrent falls) also novel classification based on pre-fall event: (1) advanced activity; (2) ambulation; (3) transition. Non-parametric statistics compared groups both classifications. RESULTS: At baseline 23 (20.7%) of had fallen, increasing 41 (36.9%) participants over 12 months. Total walking significantly lower for transition fallers non-fallers ambulation (p 0.041), who increased severity. There no significant relationships when frequency. We present inverted U curve model depicting PD, propose that at this stage occupy different places curve. CONCLUSIONS: Falls more common than recognised newly-diagnosed PD. Daily reduced even people during transitions. Classification methods take event into account useful understand heterogeneity complex problem. Language: en