Effect of penetrating ionising radiation on the mechanical properties of pericardium
作者： Eman Daar , E. Woods , J.L. Keddie , A. Nisbet , D.A. Bradley
DOI: 10.1016/J.NIMA.2009.11.007
关键词: Elastic modulus 、 Irradiation 、 Ionizing radiation 、 Biomedical engineering 、 Bovine pericardium 、 Pericardium 、 Physics 、 Ultimate tensile strength 、 Elastin 、 Stress relaxation
摘要: Abstract The pericardium is an anistropic composite material made up of collagen and elastin fibres embedded in amorphous matrix mainly composed proteoglycan hyaluronan. are arranged layers, with different directions alignment each layer, giving rise to interesting mechanical properties pericardium, including the ability undergo large deformation during performance regular physiological functions. present study aims investigate effect penetrating photon ionising radiation on bovine tissue, being part a cardiac doses received breast radiotherapy possibility that this can give cardiovascular complications. Irradiation range 5–80 Gy were used. To characterise various [elastic modulus, stress relaxation, ultimate tensile strength (UTS) fracture] uniaxial test method was applied. preliminary results reflect wide inter-sample variations expected dealing tissues, only weak indication increase UTS tissue dose. Such has also been observed by others, reduction at 80 Gy.
core.ac.uk
harvard.edu
elsevier.com
sci-hub.se 参考文章(11)
Allen J. Bailey, Effect of Ionizing Radiation on Connective Tissue Components International review of connective tissue research. ,vol. 4, pp. 233- 281 ,(1968) , 10.1016/B978-1-4831-6754-1.50012-1
F. Mohamed, D.A. Bradley, C.P. Winlove, Effects of ionizing radiation on extracellular matrix Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. ,vol. 580, pp. 566- 569 ,(2007) , 10.1016/J.NIMA.2007.05.236
A.M. Gaya, R.F.U. Ashford, Cardiac complications of radiation therapy Clinical Oncology. ,vol. 17, pp. 153- 159 ,(2005) , 10.1016/J.CLON.2004.09.016
C.W. Taylor, P. McGale, S.C. Darby, Cardiac Risks of Breast-cancer Radiotherapy: A Contemporary View Clinical Oncology. ,vol. 18, pp. 236- 246 ,(2006) , 10.1016/J.CLON.2005.11.003
Richard Skalak, Y. C. Fung, Biomechanics: Mechanical Properties of Living Tissues ,(1981)
Steven L Hancock, Margaret A Tucker, Richard T Hoppe, Factors Affecting Late Mortality From Heart Disease After Treatment of Hodgkin's Disease JAMA: The Journal of the American Medical Association. ,vol. 270, pp. 1949- 1955 ,(1993) , 10.1001/JAMA.1993.03510160067031
Eman Daar, L. King, A. Nisbet, R.B. Thorpe, D.A. Bradley, Viscosity changes in hyaluronic acid: irradiation and rheological studies. Applied Radiation and Isotopes. ,vol. 68, pp. 746- 750 ,(2010) , 10.1016/J.APRADISO.2009.10.022
J. H. Bowes, J. A. Moss, The Effect of Gamma Radiation on Collagen Radiation Research. ,vol. 16, pp. 211- 223 ,(1962) , 10.2307/3571153
J M Lee, D R Boughner, Tissue mechanics of canine pericardium in different test environments. Evidence for time-dependent accommodation, absence of plasticity, and new roles for collagen and elastin. Circulation Research. ,vol. 49, pp. 533- 544 ,(1981) , 10.1161/01.RES.49.2.533
D. Mavrilas, E.A. Sinouris, D.H. Vynios, N. Papageorgakopoulou, Dynamic mechanical characteristics of intact and structurally modified bovine pericardial tissues. Journal of Biomechanics. ,vol. 38, pp. 761- 768 ,(2005) , 10.1016/J.JBIOMECH.2004.05.019