AFM and uni-axial testing of pericardium exposed to radiotherapy doses
作者： Eman Daar , W. Kaabar , C. Lei , J.L. Keddie , A. Nisbet
DOI: 10.1016/J.NIMA.2010.08.059
关键词: Atomic force microscopy 、 Fibril 、 Physics 、 Extracellular matrix 、 Biomedical engineering 、 Radiation therapy 、 Elastin 、 Collagen fibres 、 Viscoelasticity 、 Pericardium
摘要: Abstract The pericardium, a double-layered sac that encloses the heart, is made up of collagen and elastin fibres embedded in an amorphous matrix (forming extracellular matrix). Collagen are aligned multidirectional orientation layers. This free arrangement gives pericardium its viscoelastic properties ability to deform all directions. important mechanical property for heart perform physiological functions, acknowledging fact attached different ligaments muscles present study aims investigate effect penetrating photon ionising radiation on bovine tissue. links interest seeking understand possible mechanisms underlying cardiac complications following treatment left breast radiotherapy regimes. Pericardium samples were subjected doses range 0–80 Gy. Atomic force microscopy (AFM) has been applied characterising changes infrastructural tissues. Preliminary data 80 Gy shows there was no significant change D-spacing period banded structure type I but increase observed FWHM fibril widths (by between 25% 27%) over unirradiated
harvard.edu
elsevier.com
sci-hub.se 参考文章(8)
M. Jastrzebska, J. Zalewska-Rejdak, R. Wrzalik, A. Kocot, I. Mroz, B. Barwinski, A. Turek, B. Cwalina, Tannic acid-stabilized pericardium tissue: IR spectroscopy, atomic force microscopy, and dielectric spectroscopy investigations. Journal of Biomedical Materials Research Part A. ,vol. 78, pp. 148- 156 ,(2006) , 10.1002/JBM.A.30717
A.M. Gaya, R.F.U. Ashford, Cardiac complications of radiation therapy Clinical Oncology. ,vol. 17, pp. 153- 159 ,(2005) , 10.1016/J.CLON.2004.09.016
M Tzaphlidou, Collagen as a model for the study of radiation induced side effects: use of image processing Micron. ,vol. 33, pp. 117- 120 ,(2002) , 10.1016/S0968-4328(01)00009-9
Manuela Venturoni, Thomas Gutsmann, Georg E Fantner, Johannes H Kindt, Paul K Hansma, Investigations into the polymorphism of rat tail tendon fibrils using atomic force microscopy. Biochemical and Biophysical Research Communications. ,vol. 303, pp. 508- 513 ,(2003) , 10.1016/S0006-291X(03)00390-5
C.W. Taylor, P. McGale, S.C. Darby, Cardiac Risks of Breast-cancer Radiotherapy: A Contemporary View Clinical Oncology. ,vol. 18, pp. 236- 246 ,(2006) , 10.1016/J.CLON.2005.11.003
Maria Jastrzebska, Iwona Mróz, Bogdan Barwiński, Justyna Zalewska-Rejdak, Artur Turek, Beata Cwalina, Supramolecular structure of human aortic valve and pericardial xenograft material: atomic force microscopy study. Journal of Materials Science: Materials in Medicine. ,vol. 19, pp. 249- 256 ,(2008) , 10.1007/S10856-006-0049-2
Eman Daar, E. Woods, J.L. Keddie, A. Nisbet, D.A. Bradley, Effect of penetrating ionising radiation on the mechanical properties of pericardium Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 619, pp. 356- 360 ,(2010) , 10.1016/J.NIMA.2009.11.007
Thomas Gutsmann, Georg E. Fantner, Johannes H. Kindt, Manuela Venturoni, Signe Danielsen, Paul K. Hansma, Force Spectroscopy of Collagen Fibers to Investigate Their Mechanical Properties and Structural Organization Biophysical Journal. ,vol. 86, pp. 3186- 3193 ,(2004) , 10.1016/S0006-3495(04)74366-0