Developmental changes in neuromagnetic rhythms and network synchrony in autism

摘要: Objective. There is gathering consensus that altered connectivity a hallmark of the autistic brain. This includes atypical neural oscillations and their coordination across brain regions, which are understood to mediate information processing integration. It remains unclear if how in various neurophysiological frequency ranges develops atypically autism spectrum disorder. Methods. To address this cross-sectional sample, we recorded resting-state magnetoencephalography (MEG) from 134 children adolescents with without ASD, calculated resting spectral power inter-regional synchrony (functional connectivity). Results. While no overall group differences were observed, significant alterations linear non-linear age-related changes oscillatory network found. These frequency- region-specific implicated systems thought play prominent role such as frontal cortex cerebellum. We also found correlations between Autism Diagnostic Observation Schedule (ADOS) scores degree cerebellar networks ‘idiosyncratic' an individual autism. Interpretation. We provide first evidence it curvatures maturational synchrony, rather than disturbances particular direction, characterizes function individuals ASD. Moreover, patterns idiosyncratic distortions relative curve associated behavioral symptoms article protected by copyright. All rights reserved.