Relaxin's physiological roles and other diverse actions.
作者： O. David Sherwood
DOI: 10.1210/ER.2003-0013
关键词: Biology 、 Receptor 、 Relaxin-3 、 Internal medicine 、 Fibrosis 、 Wound healing 、 Endocrinology 、 Relaxin 、 Pregnancy 、 Relaxin receptor 、 Kidney
摘要: Relaxin has vital physiological roles in pregnant rats, mice, and pigs. promotes growth softening of the cervix, thus facilitating rapid delivery live young. also development mammary apparatus, enabling normal lactational performance. The actions relaxin on apparatus vary among species. Whereas is required for nipples rats it essential prepartum glandular parenchyma During pregnancy inhibits uterine contractility osmoregulatory changes rats. Recent studies with male nonpregnant female rodents revealed diverse therapeutic nonreproductive tissues that have clinical implications. been reported to reduce fibrosis kidney, heart, lung, liver promote wound healing. Also, probably through its vasodilatory actions, protects heart from ischemia-induced injury. Finally, counteracts allergic reactions. Knowledge relaxin, coupled recent identification receptors, opens numerous avenues investigation will likely sustain a high level research interest foreseeable future.
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