Antifungal dynamics of LY 303366, an investigational echinocandin B analog, against Candida ssp.

摘要: Two isolates each of Candida albicans, tropicalis, and glabrata were selected for time-kill curve testing against LY 303366 at concentrations ranging from 0.125 x MIC to 16 MIC. RPMI 1640 buffered morpholinepropanesulfonic acid (MOPS) was utilized as growth medium. Samples obtained predetermined time points over 24 hours streaked colony count determination. Against C. albicans (one strain) isolates, exhibited fungicidal (> or = three log10 reduction in CFU) activity. In contrast, fungistatic activity observed with tropicalis all the multiples tested. With exception one strain, rate extent test not enhanced exceeding Our data indicate that maximal antifungal may be achieved by optimizing fungal exposure drug. Additionally, these suggest use current interpretive endpoint MICs underestimate 303366. Thus, need re-evaluated, perhaps an alternative media, such antibiotic medium #3, should determination MICs.