Effect of intraluteal injection of endothelin type A receptor antagonist on PGF2alpha-induced luteolysis in the cow.
作者： Sho WATANABE , Koumei SHIRASUNA , Motozumi MATSUI , Dai YAMAMOTO , Bajram BERISHA
DOI: 10.1262/JRD.18018
关键词: Internal medicine 、 Receptor antagonist 、 Endocrinology 、 Luteal phase 、 Antagonist 、 Luteolysis 、 Endothelin receptor 、 Endothelin 1 、 Corpus luteum 、 Estrous cycle 、 Biology
摘要: Endothelin-1 (ET-1) is a luteolytic mediator in the bovine corpus luteum (CL), and its action appears to be via endothelin type A receptor (ETR-A). Thus, aim of present study was determine effect ETR-A antagonist on PGF2α-induced luteolysis cow. Cows days 10-12 estrous cycle were subjected five intraluteal injections LU 135252 saline or only at -0.5, 2, 4, 6, 8 h after PGF2α administration (=0 h). Serial luteal biopsies conducted expression mRNA tissue. There no significant differences decrease plasma progesterone (P) concentrations expressions steroidogenic acute regulatory protein 3β-hydroxysteroid dehydrogenase/Δ5, Δ4-isomerase between antagonist-treated group control group. However, start decline CL volume blood flow area surrounding delayed for almost two compared The preproET-1 B increased both groups, while remained unchanged. In addition, caspase-3 significantly 24 level higher than that suggests ET-1 regulates structural by controlling vessel contraction
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