Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints.
作者： Paul J. Wang , Andrew J. Saykin , Laura A. Flashman , Heather A. Wishart , Laura A. Rabin
DOI: 10.1016/J.NEUROBIOLAGING.2005.09.035
关键词: Alzheimer's disease 、 Magnetic resonance imaging 、 Psychiatry 、 Splenium 、 Corpus callosum 、 Psychology 、 Case-control study 、 Audiology 、 Cognition 、 Neuropsychology 、 Atrophy
摘要: The goal of the present study was to determine if there are global or regionally specific decreases in callosal area early Alzheimer’s disease (AD) and mild cognitive impairment (MCI). In addition, this examined corpus callosum healthy older adults who have subjective complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure examine total regional areas 22 patients with AD, 28 amnestic MCI, complaints, 50 demographically matched controls (HC). CC groups all showed significant reduction posterior region (isthmus splenium) relative controls. AD group also had significantly smaller overall than demonstration atrophy suggests that changes occur very dementing process, these earliest may be too subtle for detection by assessments, including memory
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