The landscape of viral expression and host gene fusion and adaptation in human cancer.

作者: Ka-Wei Tang , Babak Alaei-Mahabadi , Tore Samuelsson , Magnus Lindh , Erik Larsson

DOI: 10.1038/NCOMMS3513

关键词: Viral integrationPathogenesisHuman cancerMassive parallel sequencingGeneticsHost geneCancer genomeBiology

摘要: … Similarly, 13q22 is a weakly preferred fragile site 26 where we … Results from LIHC confirmed recurrent HBV fusions with … breakpoint-spanning reads that aligned in part to Hg19 and in …

参考文章(48)
J. D. Storey, R. Tibshirani, Statistical significance for genomewide studies Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 9440- 9445 ,(2003) , 10.1073/PNAS.1530509100
Deepti Joshi, Gertrude Case Buehring, Are viruses associated with human breast cancer? Scrutinizing the molecular evidence. Breast Cancer Research and Treatment. ,vol. 135, pp. 1- 15 ,(2012) , 10.1007/S10549-011-1921-4
Patrick S. Moore, Yuan Chang, Why do viruses cause cancer? Highlights of the first century of human tumour virology Nature Reviews Cancer. ,vol. 10, pp. 878- 889 ,(2010) , 10.1038/NRC2961
Margaret E. McLaughlin-Drubin, Karl Münger, The human papillomavirus E7 oncoprotein. Virology. ,vol. 384, pp. 335- 344 ,(2009) , 10.1016/J.VIROL.2008.10.006
M Narisawa-Saito, K Handa, T Yugawa, S Ohno, M Fujita, T Kiyono, HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytes. Oncogene. ,vol. 26, pp. 2988- 2996 ,(2007) , 10.1038/SJ.ONC.1210118
Chang-Min Kim, Kazuhiko Koike, Izumu Saito, Tatsuo Miyamura, Gilbert Jay, HBx gene of hepatitis B virus induces liver cancer in transgenic mice Nature. ,vol. 351, pp. 317- 320 ,(1991) , 10.1038/351317A0
P-A. Larsson, S. Edström, T. Westin, A. Nordkvist, J. M. Hirsch, A. Vahlne, Reactivity against herpes simplex virus in patients with head and neck cancer. International Journal of Cancer. ,vol. 49, pp. 14- 18 ,(1991) , 10.1002/IJC.2910490104
M Peter, C Rosty, J Couturier, F Radvanyi, H Teshima, X Sastre-Garau, MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors Oncogene. ,vol. 25, pp. 5985- 5993 ,(2006) , 10.1038/SJ.ONC.1209625
Emmanuel Barillot, Patricia de Cremoux, Paul Cottu, Francois Radvanyi, Xavier Sastre-Garau, Martine Peter, Nicolas Stransky, Jérôme Couturier, Philippe Hupé, Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma The Journal of Pathology. ,vol. 221, pp. 320- 330 ,(2010) , 10.1002/PATH.2713
Gary Clifford, Silvia Franceschi, Mireia Diaz, Nubia Muñoz, Luisa Lina Villa, None, Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases Vaccine. ,vol. 24, pp. S26- S34 ,(2006) , 10.1016/J.VACCINE.2006.05.026