Reactivity against herpes simplex virus in patients with head and neck cancer.
作者： P-A. Larsson , S. Edström , T. Westin , A. Nordkvist , J. M. Hirsch
关键词: Antibody 、 Antibody titer 、 Herpes simplex virus 、 Head and neck cancer 、 Western blot 、 Herpesviridae 、 Cancer 、 Virus 、 Immunology 、 Medicine
摘要: The relation between herpes simplex virus (HSV) and head neck cancer was examined. A total of ninety patients were analyzed for IgG antibodies against HSV. Antibody titers established with an enzyme-linked immunosorbent assay specific HSV-antigens by Western blot. These patients' seroreactivity compared to that age-matched control group arteriosclerotic disease in their lower limbs, a also closely related heavy tobacco consumption. Prevalence HSV around 90% did not differ significantly controls, but antibody higher the patients. reacted more constantly (80%) blot analysis early immediate protein, ICP-4, than controls (50%). This suggests different course earlier herpetic infection these prolonged exposure HSV-proteins which may be increased risk developing cancer. We propose smoking contribute this phenomenon.
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