Nasal sodium cromoglycate (Lomusol) modulates the early phase reaction of mild to moderate persistent allergic rhinitis in patients mono-sensitized to house dust mite: A preliminary study
作者： Margaux Lejeune , Philipe P. Lefebvre , Philippe Delvenne , Amr E. El-Shazly
DOI: 10.1016/J.INTIMP.2015.02.004
关键词: Eosinophil 、 Nasal spray 、 Immunology 、 Chemistry 、 Histamine 、 Platelet-activating factor 、 House dust mite 、 Eosinophil cationic protein 、 Eosinophil degranulation 、 Allergen
摘要: We evaluated the clinical improvement of patients with mild to moderate persistent allergic rhinitis (AR) due mono-sensitization house dust mite (HDM) allergen, by sodium cromoglycate nasal spray (Lomusol 4%). Lomusol was used as a single agent treatment, and its anti-inflammatory effects, in early phase reaction were evaluated. Herein we showed that significantly improved subjective symptom scores especially obstruction. This associated significant specific reduction neutrophils influx cytology but had no effect on other cell types. selective levels platelet activating factor (PAF) histamine secretions PGD2, LTC4 or CysLt levels. also able induce eosinophil cationic protein (ECP) without altering percentage cytology. Taken collectively, first evidence possesses inhibition neutrophil recruitment into AR mono-sensitized HDM. may be attributed ability reduce amount PAF recovered secretion. These results obstruction addition, down-regulate degranulation activity well.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(19)
Grazyna Galatowicz, Yetunde Ajayi, Michael E. Stern, Virginia L. Calder, Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo. Clinical & Experimental Allergy. ,vol. 37, pp. 1648- 1656 ,(2007) , 10.1111/J.1365-2222.2007.02782.X
J. S. G. COX, Disodium Cromoglycate (FPL 670) (‘Intal’ * ): a Specific Inhibitor of Reaginic Antibody–Antigen Mechanisms Nature. ,vol. 216, pp. 1328- 1329 ,(1967) , 10.1038/2161328A0
Tao Du, Santo Sapienza, Chong G. Wang, Paolo M. Renzi, Rosa Pantano, Paola Rossi, J.G. Martin, Effect of nedocromil sodium on allergen-induced airway responses and changes in the quantity of airway smooth muscle in rats. The Journal of Allergy and Clinical Immunology. ,vol. 98, pp. 400- 407 ,(1996) , 10.1016/S0091-6749(96)70164-1
David Price, Christine Bond, Jacques Bouchard, Rui Costa, Joseph Keenan, Mark L. Levy, Mari Orru, Dermot Ryan, Samantha Walker, Margaret Watson, International Primary Care Respiratory Group (IPCRG) Guidelines: management of allergic rhinitis. Primary Care Respiratory Journal. ,vol. 15, pp. 58- 70 ,(2006) , 10.1016/J.PCRJ.2005.11.002
J.S.G. Cox, R.E.C. Altounyan, Nature and Modes of Action of Disodium Cromoglycate (Lomudal Respiration. ,vol. 27, pp. 292- 309 ,(1970) , 10.1159/000192762
S Scandale, Denise K Sur, Treatment of allergic rhinitis South African Family Practice. ,vol. 52, pp. 398- 403 ,(2010)
Franco Frati, Matteo Gelardi, Diego Peroni, Cristoforo Incorvaia, Nicola Quaranta, Concetta De Luca, Salvatore Barberi, Ilaria Dell'Albani, Massimo Landi, Olivier de Beaumont, Seasonal changes in nasal cytology in mite-allergic patients Journal of Inflammation Research. ,vol. 7, pp. 39- 44 ,(2014) , 10.2147/JIR.S54581
J.R. Lapa e Silva, C. Ruffié, B.B. Vargaftig, M. Pretolani, Modulation of the bronchial inflammation in sensitized guinea-pigs by FK506, nedocromil sodium and dexamethasone European Respiratory Journal. ,vol. 8, pp. 1321- 1327 ,(1995) , 10.1183/09031936.95.08081321
C. H. Katelaris, B. W. Lee, P. C. Potter, J. F. Maspero, C. Cingi, A. Lopatin, M. Saffer, G. Xu, R. D. Walters, Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America Clinical & Experimental Allergy. ,vol. 42, pp. 186- 207 ,(2012) , 10.1111/J.1365-2222.2011.03891.X
J. Bousquet, N. Khaltaev, A. A. Cruz, J. Denburg, W. J. Fokkens, A. Togias, T. Zuberbier, C. E. Baena-Cagnani, G. W. Canonica, C. Van Weel, I. Agache, N. Aït-Khaled, C. Bachert, M. S. Blaiss, S. Bonini, L.-P. Boulet, P.-J. Bousquet, P. Camargos, K.-H. Carlsen, Y. Chen, A. Custovic, R. Dahl, P. Demoly, H. Douagui, S. R. Durham, R. Gerth Van Wijk, O. Kalayci, M. A. Kaliner, Y.-Y. Kim, M. L. Kowalski, P. Kuna, L. T. T. Le, C. Lemiere, J. Li, R. F. Lockey, S. Mavale-Manuel, E. O. Meltzer, Y. Mohammad, J. Mullol, R. Naclerio, R. E. O’Hehir, K. Ohta, S. Ouedraogo, S. Palkonen, N. Papadopoulos, G. Passalacqua, R. Pawankar, T. A. Popov, K. F. Rabe, J. Rosado-Pinto, G. K. Scadding, F. E. R. Simons, E. Toskala, E. Valovirta, P. Van Cauwenberge, D.-Y. Wang, M. Wickman, B. P. Yawn, A. Yorgancioglu, O. M. Yusuf, H. Zar, I. Annesi-Maesano, E. D. Bateman, A. Ben Kheder, D. A. Boakye, J. Bouchard, P. Burney, W. W. Busse, M. Chan-Yeung, N. H. Chavannes, A. Chuchalin, W. K. Dolen, R. Emuzyte, L. Grouse, M. Humbert, C. Jackson, S. L. Johnston, P. K. Keith, J. P. Kemp, J.-M. Klossek, D. Larenas-Linnemann, B. Lipworth, J.-L. Malo, G. D. Marshall, C. Naspitz, K. Nekam, B. Niggemann, E. Nizankowska-Mogilnicka, Y. Okamoto, M. P. Orru, P. Potter, D. Price, S. W. Stoloff, O. Vandenplas, G. Viegi, D. Williams, Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) Allergy. ,vol. 63, pp. 8- 160 ,(2008) , 10.1111/J.1398-9995.2007.01620.X