What we know about gastroesophageal reflux disease and obstructive sleep apnea
作者： Cristina Salles , Álvaro Augusto Cruz , Regina Terse Trindade Ramos , Andrea Barral , Larissa Monteiro
DOI:
关键词: Sleep apnea 、 GERD 、 Clinical trial 、 Hypopnea 、 Internal medicine 、 Medicine 、 Randomized controlled trial 、 Apnea 、 Obstructive sleep apnea 、 Polysomnography 、 Physical therapy
摘要: Objectives: The primary objective of this systematic review is assessing whether treatment gastroesophageal disease (GERD) may reduce the apnea and hypopnea index (HAI) secondary there a correlation between HAI acid reflux. Methods: Using clinical studies that investigated relationship obstructive sleep GERD. search included all cited publications up to April 22, 2012, using keywords “sleep apnea, obstructive” AND “gastroesophageal reflux/diagnosis” OR reflux/drug therapy” reflux/therapy” “randomized controlled trial”. following electronic databases were used: PubMed, EMBASE, LILACS, MedLine, SCISEARCH, WEB Science, CINAHL, BIREMI, SCOPUS, database trials COCHANE collaboration. total sample size was 60 patients (55% males). All in eligible submitted both polysomnography esophageal pH measurements before after treatment. Results: Initially, 24 articles selected. Of these, only three met criteria for study 3 found analysis “before after” trials. Through grouping our review, we statistically significant decline average time GERD treatment, trend reduction rate HAI. Conclusion: examined demonstrate medical hypopnea. Nevertheless, more are needed confirm benefits drug therapy context apnea.
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