Nitric Oxide Synthase (NOS)-Interacting Protein Interacts with Neuronal NOS and Regulates Its Distribution and Activity
作者： Jacqueline Dreyer , Michael Schleicher , Anke Tappe , Kirstin Schilling , Thomas Kuner
DOI: 10.1523/JNEUROSCI.2265-04.2004
关键词: Biology 、 Colocalization 、 Kainic acid 、 Nitric oxide synthase 、 Neuroscience 、 Premovement neuronal activity 、 Nitric oxide 、 COS cells 、 Nervous system 、 Cell biology 、 Endogeny
摘要: Mechanisms governing the activity of neuronal nitric oxide synthase (nNOS), major source (NO) in nervous system, are not completely understood. We report here a protein-protein interaction between nNOS and NOSIP (nitric synthase-interacting protein) rat brain vivo. concentrated synapses demonstrate significant colocalization various regions central peripheral systems. produces reduction neuroepithelioma cell line stably expressing nNOS. Furthermore, overexpression cultured primary neurons reduces availability terminal dendrites. These results thus suggest that is functionally involved endogenous mechanisms regulating NO synthesis. we found subcellular distribution expression levels dynamically regulated by vitro as well vivo, suggesting may contribute to mechanism via which regulates synaptic
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