Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH–AARP Diet and Health Study Cohort

摘要: Previous studies have reported that lung cancer risk may be decreased, increased, or unaffected by prior use of menopausal hormone therapy (MHT). To assess this issue further, we examined relationships among 118,008 women, ages 50–71 years who were recruited during 1995–1996 for the NIH–AARP Diet and Health Study in whom 2,097 incident carcinomas identified follow-up through 2006. Multivariable Cox proportional hazards models estimated relative risks (RR) 95% confidence intervals (CIs) associated with various measures self-reported MHT use. We found no evidence either estrogen (ET)-only plus progestin (EPT) was substantially related to subsequent (respective RRs CIs ever use = 0.97, 0.86–1.09 1.03, 0.90–1.17). There significant variations according currency duration formulation, nor there varied within subgroups defined cigarette smoking body size. The absence effect seen nearly all subtypes, exception an increased undifferentiated/large cell cancers long-term ET-only (p trend = 0.02), a relationship not observed EPT users. Our results failed support any substantial alterations unopposed MHT, even when detailed exposure other predictors considered.