作者: Thomas O’Reilly-Pol , Stephen L. Johnson
DOI: 10.1016/J.SEMCDB.2008.09.007
关键词: Stem cell factor 、 Stem cell 、 Biology 、 Cell biology 、 Adult stem cell 、 Immunology 、 Stem cell transplantation for articular cartilage repair 、 Mesenchymal stem cell 、 Cellular differentiation 、 Regeneration (biology) 、 Zebrafish
摘要: Utilization of adult stem cells in regenerative therapies may require a thorough understanding the mechanisms that establish, recruit and renew cell, promote differentiation its daughters, or how cell is repressed by target tissue. Regeneration melanocytes regenerating zebrafish caudal fin, following larval melanocyte-specific ablation, recruitment new during pigment pattern metamorphosis each provides evidence for melanocyte (MSCs) support pattern. We discuss MSC regulation provided from analysis normal mutant regeneration these systems, including implications drawn does not simply recapitulate ontogenetic development. These results suggest will provide fine scale dissection establishing regulating cells.