Role of nonenzymatic glycosylation in experimental cataract formation
作者： Shyh-Horng Chiou , Leo T. Chylack , H.Franklin Bunn , Jin H. Kinoshita
DOI: 10.1016/0006-291X(80)90871-2
关键词: Galactose 、 Cataract formation 、 Aldose reductase inhibitor 、 Biochemistry 、 Sorbinil 、 Glycation 、 Lens protein 、 Chemistry 、 Glycosylation 、 Cataracts
摘要: Abstract The relevance of nonenzymatic glycosylation lens proteins to cataract formation was studied in rats on a normal and high galactose diet, treated with without sorbinil, an aldose reductase inhibitor. All galactosemic not receiving sorbinil had cataracts; none cataracts. Lens homogenate 200 fold molar excess [3H]-borohydride the extent estimated from radioactivity incorporation quantitation hexitol-lysine adduct after extensive dialysis. We found no differences uptake nor amounts lenses sorbinil. Thus, responsible for sugar-induced
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