Effects of dietary enrichment with eicosapentaenoic acid upon autoimmune nephritis in female NZBXNZW/F1 MICE
作者： James D. Prickett , Dwight R. Robinson , Alfred D. Steinberg
关键词: Antibody 、 Endocrinology 、 Inflammation 、 Proteinuria 、 Eicosapentaenoic acid 、 Menhaden Oil 、 Internal medicine 、 Biology 、 Nephritis 、 Beef Tallow 、 Weaning
摘要: A menhaden oil diet, rich in eicosapentaenoic acid, protected female NZB X NZW/F1 mice from autoimmune nephritis. Only 15% of treated with the diet weaning had died severe renal disease at 19 months, versus 98% controls on a beef tallow diet. The also these when instituted 4 and 5 months age and, under conditions, levels anti-native DNA antibodies were similar both dietary groups. Our data suggest that may act primarily to reduce inflammation via ability acid alter production prostaglandins leukotrienes.
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