Allogeneic nerve grafts in the rat, with special reference to the role of Schwann cell basal laminae in nerve regeneration.

摘要: The role of basal laminae as conduits for regenerating axons in an allogeneic graft was examined by transplanting a 3 cm long segment the sciatic nerve from Brown Norway to Fischer 344 strain rat. These strains are not histocompatible with each other. In order compare regeneration variously treated grafts, three different types were employed: non-treated (NT), predenervated (PD), and plus freeze-treated (PDC) grafts. cytology through these grafts electron microscopy at four, seven, 14, 30 60 days after grafting. PDC graft, which Schwann cells dead on grafting, well preserved form tubes myelin sheaths had been removed seven Regenerating accompanied immature host grew out such lamina same fashion observed our previous studies. By day extended far middle graft. proximal part they separated into individual fibres even thinly myelinated cells. On other hand, NT PD alive most appeared undergo autolytic degeneration while cell left almost intact tubes. A few seen associated portion seven. It is probable that moved donor degraded. tended be damaged site extensive lymphoid infiltration. 30, arrived distal end all graft: thick fully myelinated, whereas only occasionally still surrounded common 1 apposition findings show can serve pathways (most efficiently graft) allograft