Smoking Cessation and Time Course of Decreased Risks of Coronary Heart Disease in Middle-Aged Women

摘要: Background: We examined prospectively the relation of time since stopping smoking with risk coronary heart disease in middle-aged women. Methods: The study was based on 12 years' follow-up data (1976 through 1988) from Nurses' Health Study, an ongoing prospective cohort study, which information habits updated every 2 years by a mailed questionnaire. population consisted 117 006 female registered nurses aged 30 to 55 1976 who were free disease, stroke, and cancer at baseline. outcome measure used incident defined as nonfatal myocardial infarction plus fatal disease. Results: A total 970 cases (215 among participants never smoked, 214 former smokers, 541 current smokers) occurred during 1.37 million person-years follow-up. multivariate relative smokers compared smoked 4.23(95% confidence interval, 3.60 4.96). Risk highest started before age 15 (relativerisk, 9.25; 95% 5.27 16.23). 1.48 (95% 1.22 1.79). On smoking, one third excess eliminated within cessation. Thereafter, returned level those interval 10 14 following Conclusion: Women stop will experience immediate benefit well further longerterm decline smoked. (Arch Intern Med. 1994;154:169-175)