Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: A positron emission tomography study

摘要: Parkinson's disease (PD) patients have remarkably reduced levels of dopaminergic biomarkers in the caudal putamen. However, relationship between motor impairments and localization intrastriatal degeneration monkey PD models remains unclear. To identify striatal areas with dysfunction responsible for impairments, we measured changes both general activity vivo three cynomolgus monkeys that repeatedly received 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), starting normal state continuing until after tremor appearance. Binding dopamine transporters (DAT) D(2) receptors were by positron emission tomography (PET) using [(11)C]PE2I [(11)C]raclopride, respectively. Region-of-interest-based regression analysis demonstrated degree reduction to be explained DAT binding but not receptor binding. Furthermore, voxel-based revealed a significant correlation decreased binding, specifically ventrolateral putamen, which corresponds area receiving upper body inputs from primary cortex. These results suggest specific functional deficits are closely related terminals subregion these functions level deficit is dependent on degeneration.