Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer

摘要: Tumor budding, a histological hallmark of epithelial-mesenchymal transition in colorectal cancer, is parameter tumor progression and according to the International Union Against Cancer/American Joint Committee on Cancer an 'additional' prognostic factor. The current definition budding reserved for invasive front cancer (so called peri-tumoral budding), but buds can also be observed small preoperative biopsy specimens. Whereas value assessed resection specimens has found wide acceptance, biopsies, which normally do not encompass margin hence intra-tumoral been systematically investigated yet. Therefore, aim this study assess predictive lymph node distant metastasis biopsies. Preoperative samples consecutive from 72 patients with pathological information TNM stage, vascular, lymphatic perineural invasion, border configuration were used evaluate budding. Both parameters scored semiquantitatively as 'high' (detectable at low power magnification × 2.5) 'low' (occasional intermediate 10, difficult find or absent). In high was 12/72 (17%) associated corresponding (P=0.008). Additionally, there correlation between (P=0.034), (P=0.007) higher grade (P=0.025). Peri-tumoral N stage (P=0.004), vascular (P=0.046) invasion (P=0.019) well infiltrating (P<0.001), reflecting progression. High predicts metastasis.